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建立了顶空毛细管气相色谱法同时测定利培酮中的甲醇、丙酮、异丙醇、乙腈、二氯甲烷、正己烷、乙酸乙酯和甲苯。采用DB-624毛细管色谱柱,程序升温,FID检测器,顶空平衡温度85℃,平衡时间20 min。上述溶剂分别在9～900、15～1 500、15～1 500、1.2～120、1.8～180、0.9～90、15～1 500和2.7～270 g/ml浓度范围内线性关系良好,回收率分别为99.4%、96.4%、104.4%、99.7%、96.3%、96.3%、97.1%和96.8%,RSD均小于2.5%。
A capillary gas chromatography was developed for the simultaneous determination of methanol, acetone, isopropanol, acetonitrile, methylene chloride, n-hexane, ethyl acetate and toluene in risperidone. The DB-624 capillary column was used to program temperature and FID detector. The equilibrium temperature was 85 ℃ and the equilibrium time was 20 min. The above solvents showed good linearity in the range of 9-900, 15-1,500, 15-1,500, 1.2-120, 1.8-180, 0.990, 15-1,500 and 2.7-270 g / ml, respectively. The recovery rate Were 99.4%, 96.4%, 104.4%, 99.7%, 96.3%, 96.3%, 97.1% and 96.8%, respectively. The RSDs were less than 2.5%.