【摘 要】
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Main observation and conclusionrnFive new sesquiterpenoids (1-5),chloranholides A-E,along with three known compounds (6-8),were isolated from the whole plants of Chloranthus holostegius.Their structures were elucidated using the spectroscopic methods (IR,
【机 构】
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Institute of Traditional Chinese Medicine & Natural Products,Guangdong Province Key Laboratory of Ph
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Main observation and conclusionrnFive new sesquiterpenoids (1-5),chloranholides A-E,along with three known compounds (6-8),were isolated from the whole plants of Chloranthus holostegius.Their structures were elucidated using the spectroscopic methods (IR,UV,HR-ESI-MS,1D and 2D NMR),and their absolute configurations were determined by the X-ray crystallography and ECD calculation.Compounds 1-8 were evaluated for their anti-inflammatory effects on LPS-induced RAW 264.7 macrophage cells.Especially,compound 4 exhibited the most significant anti-inflammatory activity with the secretion levels of TNF-α and IL-6 at 15.52％ and 5.98％,respectively,better than that of dexamethasone.
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