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目的 :针对一粒金胶囊的功能与主治 ,对其进行主要药效学实验研究。方法 :镇痛试验采用小鼠扭体法、热板法和鼠尾电刺激法 3种方法 ;镇静、催眠试验采用小鼠自主活动试验和小鼠睡眠试验2种方法 ;活血化瘀试验采用寒凝型血瘀大鼠模型 ,观察其对血液流变学指标的影响 ,以及对兔耳血管灌流量的影响。结果 :一粒金胶囊能显著抑制因化学刺激、热刺激、电刺激所引起的疼痛反应 ;能明显抑制小鼠的自主活动 ;对戊巴比妥钠的催眠有协同作用 ;能改善寒凝型血瘀大鼠的各项血液流变学指标 ,能显著增加兔耳血管灌流量。结论 :一粒金胶囊具有镇痛、镇静及活血化瘀作用。
Objective: To study the main pharmacodynamics of a gold capsule in terms of its function and indication. Methods: Thirty methods such as mouse writhing method, hot plate method and rat tail electrical stimulation method were used for analgesia test; two methods were used for sedation and hypnosis test: mouse spontaneous activity test and mouse sleep test; The coagulation blood stasis rat model was used to observe the effect on blood rheology parameters and the effect on rabbit ear vascular irrigation. RESULTS: A gold capsule could significantly inhibit the pain reaction caused by chemical stimuli, thermal stimulation and electrical stimulation; it could significantly inhibit the mice’s autonomous activities; had a synergistic effect on the hypnotic effect of pentobarbital sodium; and could improve the cold coagulation type. The blood rheological parameters of blood stasis rats can significantly increase the rabbit ear vascular irrigation. Conclusion : A gold capsule has analgesic, sedative and blood circulation effects.