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氟与脂质过氧化作用的关系仍不清楚。本文报告了短期饮用加入氟化钠的水对大鼠胶质过氧化作用的影响。结果表明,氟化钠具有刺激血清总巯基升高的作用,但当氟化物浓度继续升高则总巯基浓度非但不再升高,反而下降到正常水平,脂质过氧化物 MDA 也呈明显下降趋势。提示,虽然体内硬组织随摄氟量增加,蓄积增加,造成损伤,但是这种损伤不是脂质过氧化作用所致,相反,氟化钠是一种弱的抗氧化剂。
The relationship between fluoride and lipid peroxidation remains unclear. This article reports the effect of short-term sodium fluoride-added water on glial peroxidation in rats. The results showed that sodium fluoride stimulated the increase of serum total mercapto group, but when the fluoride concentration continued to increase, the total sulfhydryl concentration not only did not increase, but dropped to normal levels, lipid peroxidation MDA also showed a significant decline trend. Tip, although the amount of fluoride in vivo hard tissue increases, the accumulation of increased, causing damage, but this damage is not caused by lipid peroxidation, on the contrary, sodium fluoride is a weak antioxidant.