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目的探讨基因重组人生长激素(recombinant human growth hormone,rhGH)及雌/孕激素(estrogen/progestogem,E/P)治疗对Turner综合征(Turner syndrome,TS)患儿身高及性征发育的影响。方法 2005年1月—2009年6月四川大学华西第二医院门诊就诊TS患儿22例,12例患儿接受rhGH治疗,年龄(13.58±2.23)岁,剂量0.15U/(kg.d),睡前皮下注射,疗程4～24个月。16例年龄≥13岁、骨龄≥11岁的患儿接受E/P治疗,疗程3～30个月。结果 rhGH治疗后患儿身高、身高的标准差积分提高,生长速率达(9.33±2.39)cm/年;E/P治疗可促进患儿乳房发育及规律月经出现。结论 rhGH和E/P治疗对TS患儿身高增长及性征发育有明显疗效。
Objective To investigate the effects of recombinant human growth hormone (rhGH) and estrogen / progestogem (E / P) therapy on the development of height and sexual characteristics in children with Turner syndrome (TS). Methods From January 2005 to June 2009, 22 children with TS were admitted to West China Second Hospital of Sichuan University. Twelve children were treated with rhGH (mean age 13.58 ± 2.23 years, 0.15U / kg.d) Subcutaneous injection before going to bed, treatment 4 to 24 months. Sixteen patients aged 13 years or older with bone age ≥11 years were treated with E / P for 3 to 30 months. Results The standard deviation integral of height and height of rhGH increased (9.33 ± 2.39) cm / year after rhGH treatment. E / P treatment promoted breast development and regular menstruation in children. Conclusion rhGH and E / P treatment have obvious curative effect on height growth and sexual development of children with TS.