Ｒｂ基因是最早被发现的抑癌基因 ,其蛋白产物是参与细胞周期调控的重要因子。近年报道Ｒｂ基因缺失及其ｍＲＮＡ表达水平与胃癌的发生有关 ,而Ｒｂ蛋白表达与胃癌的关系尚不清楚。本研究采用Ｓ -Ｐ免疫组织化学方法检测胃癌中Ｒｂ蛋白表达 ,明确其在胃癌的生物学行为及临床分 The Rb gene is the earliest discovered tumor suppressor gene, and its protein product is an important factor involved in cell cycle regulation. In recent years, it has been reported that Rb gene deletion and its mRNA expression levels are related to the occurrence of gastric cancer, and the relationship between Rb protein expression and gastric cancer is not yet clear. In this study, S-P immunohistochemical method was used to detect the expression of Rb protein in gastric cancer, and its biological behavior and clinical score in gastric cancer were clarified.