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目前对大剂量所致的放射损伤治疗中,用骨髓移植措施仅在一定照射剂量范围内有效。超过一定范围时,机体由于小肠组织的严重损伤而出现早期肠型死亡。如能在骨髓移植前采用某种防护效价较高的抗辐射药物来降低辐射效应和保护肠道,便有可能获得较好的防治效果。 WR-2721是一个有较高效价的抗辐射药物。但用药量较大,并有一定副作用,我们曾将药量降至2—5mg时仍具有一定的防护效果。这就为该药的伍用提供了基
At present, in the treatment of radiation injury caused by large doses, the measures of bone marrow transplantation are effective only within a certain radiation dose range. More than a certain range, the body due to the serious injury of intestinal tissue and early intestinal-type death. If the bone marrow transplantation before the use of a protective titers higher anti-radiation drugs to reduce radiation effects and protect the intestine, it may be possible to get better control effect. WR-2721 is a higher price of anti-radiation drugs. However, larger doses, and have some side effects, we have reduced the dose to 2-5mg still have some protective effect. This provides the basis for the drug’s use