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变态反应在分泌性中耳炎发病机制中起一定作用的观点继续为新近的研究所支持。本综述说明，现已观察到的变态反应与分泌性中耳炎的关系是由鼻及鼻咽粘膜肥大细胞、其它炎性细胞和上皮细胞分泌释放的炎性介质、细胞因子及集落刺激因子所介导的。这些物质通过某种机制，如直接产生局部损伤或诱发神经、血管介导的咽鼓管开放压变化及中耳血流量变化等，引起咽鼓管阻塞，阻塞时间稍长则中耳腔呼吸气中氮被吸收，几天后中耳腔内便形成持续的负压，进而导致中耳渗出。目前还没有研究资料能够说明，在特定的人群中，抗变态反应疗法能有效地预防分泌性中耳炎发生或缩短其病程，故变态反应与分泌性中耳炎之间的关系仍然是一个值得探讨的问题。
The notion that allergies play a role in the pathogenesis of secretory otitis media continues to support recent research. This review shows that the relationship between allergic reaction and secretory otitis media has been observed to be mediated by the secretion of inflammatory mediators, cytokines and colony stimulating factors from nasal and nasopharyngeal mucosal mast cells, other inflammatory cells and epithelial cells of. These substances through a certain mechanism, such as direct local injury or induced nerve, vascular-mediated changes in the eustachian tube open pressure and changes in blood flow in the middle ear, causing eustachian tube obstruction, obstruction for a longer time in the middle ear cavity breathing Nitrogen is absorbed, a few days later in the middle ear cavity will form a sustained negative pressure, which led to the middle ear exudation. There is no data available to show that in specific populations, anti-allergy therapy can effectively prevent the occurrence of secretory otitis media or shorten its course, so the relationship between allergy and secretory otitis media is still a question worth exploring.