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近年的研究显示,凋亡抑制基因Bcl-xl在胰腺癌中呈高表达。Bcl-xl高表达与胰腺癌放疗耐受,吉西他滨和TRAIL耐药及胰腺癌预后差有关。Bcl-xl小分子抑制剂和反义寡核苷酸等靶向治疗能较好地抑制胰腺癌细胞生长。此外,Bcl-xl还与导管内乳头状瘤的癌变,胰岛细胞肿瘤的侵袭转移有关。笔者综述相关文献,旨在深入研究胰腺癌中Bcl-xl表达,有利于了解其与胰腺癌的发生特别是与耐药性的关系,为胰腺癌的临床治疗提供重要理论依据。
Recent studies have shown that apoptosis-inhibiting gene Bcl-xl is highly expressed in pancreatic cancer. Bcl-xl overexpression is associated with radiotherapy tolerance to pancreatic cancer, gemcitabine and TRAIL resistance, and poor prognosis of pancreatic cancer. Bcl-xl small molecule inhibitors and antisense oligonucleotides and other targeted therapy can better inhibit pancreatic cancer cell growth. In addition, Bcl-xl also with ductal papillomatosis, pancreatic islet cell tumor invasion and metastasis. The author summarizes the relevant literature, in order to study in-depth study of Bcl-xl expression in pancreatic cancer is conducive to understanding its relationship with the occurrence of pancreatic cancer, especially with drug resistance, providing an important theoretical basis for the clinical treatment of pancreatic cancer.