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目的 探讨尿NAG活性测定在泌尿系结石患者肾功能早期损伤方面应用价值 .方法 检测 32例泌尿系结石血、尿N -乙酰 - β -D氨基葡萄糖苷酶 (NAG)活性及尿 β2 -微球蛋白 ( β2 -MG)、血尿素氮 (BUN)、肌酐 (Cr)等指标 ,并与 5 0例正常人群组作对照比较 .结果 泌尿系结石患者血NAG水平与对照组比较基本无变化 (p >0 0 5 ) ,BUN、Cr无异常 ,尿NAG活性 ( 37 70± 2 1 5 8U/gcr)、β2 -MG水平 ( 5 31± 42 6 μg/L) ,明显高于健康对照组 (p <0 0 1) ,且两者呈显著正相关 (r=0 6 96 6 ,p <0 0 1) ,泌尿系结石合并肾积水患者 5例尿NAG及 β2 -MG水平全部大幅度升高 ,与未伴肾积水组比较有显著性差异 (p<0 0 1) .结论 泌尿系结石患者肾功能是受损伤的 ,血NAG及BUN、Cr不能反应映患者肾功能早期损伤 ,考虑测定条件等因素 ,尿NAG活性比β2 -MG是一种更为理想肾功能早期损伤的监测指标
Objective To investigate the value of urinary NAG activity determination in the early stage of renal function injury in patients with urolithiasis.Methods Totally 32 urinary calculi, urine N-acetyl-β-D-glucosaminidase (NAG) (Β2-MG), blood urea nitrogen (BUN) and creatinine (Cr) were measured and compared with 50 healthy controls.Results There was almost no change in blood NAG levels in patients with urinary calculi compared with the control group (P> 0.05), no abnormality of BUN and Cr, urinary NAG activity (37 70 ± 2 1 58 U / gcr) and β 2 -MG 5 31 ± 42 6 μg / L were significantly higher than those in healthy controls p <0.01), and there was a significant positive correlation between them (r = 0 6 96 6, p 0 01). Urinary calculi with hydronephrosis in 5 patients with urinary NAG and β 2 -MG all significantly increased (P <0.01) .Conclusion Renal function is impaired in patients with urinary calculi, blood NAG and BUN, Cr can not reflect the early renal damage in patients with renal dysfunction, consider Measurement conditions and other factors, urinary NAG activity than β2-MG is a more ideal indicators of early renal damage monitoring