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作者报导的一种简单的门诊维持缓解方案使24名急性非淋巴细胞性白血病患者的中数完全缓解期达到16.5月,21%患者缓解期超过3年。24例中,男15例,女9例,患者中数年龄为44.5岁(17~72岁)。所有患者都以强烈的诱导化疗获得完全缓解后,给予每周一次的维持化疗方案,即6—硫代鸟嘌呤2毫克/公斤,连续口服4天,接着于第5天肌内注射阿糖胞苷1.5毫克/公斤。肌内注射可由患者自己或患者家属在家里进行。每月给患者作一次体格检查和血常规检查,同时还进行血清碱性磷酸酶、血清谷-草转氨酶和血清胆红素的测定。24名患者的中数完全缓解期为16.5月(3~56个
The authors reported that a simple outpatient maintenance remission program resulted in a median complete remission period of 16.5 months in 24 patients with acute non-lymphocytic leukemia and 21% of patients with remission periods of more than 3 years. In 24 cases, there were 15 males and 9 females. The median age of patients was 44.5 years (17-72 years old). All patients received complete remission with strong induction of chemotherapy, followed by a weekly maintenance chemotherapy regimen, 6-thioguanine 2 mg/kg, continuous oral administration for 4 days, followed by intramuscular injection of arabinose on the 5th day. Aglycone 1.5 mg/kg. Intramuscular injections can be performed by the patient himself or the patient’s family at home. A monthly physical examination and blood tests were performed on the patient. Serum alkaline phosphatase, serum trough-grass aminotransferase, and serum bilirubin were also measured. The median number of complete remissions for 24 patients was 16.5 months (3 to 56