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目的探讨葡萄籽提取物对人体的抗氧化作用。方法将106例年龄在45～65岁之间的健康志愿者按血清丙二醛含量随机分为试食组和对照组,受试组连续服用受试物180d。测定血清中丙二醛(MDA)含量及超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)活性和安全性指标。结果试食后试食组丙二醛含量明显下降,下降率为5.91%;超氧化物歧化酶活性明显升高,与对照组试食后及自身试验前后比较差异均有统计学意义(P<0.05),升高率为17.41%;谷胱甘肽过氧化物酶活性明显升高,升高率为7.37%。各项安全性指标试验前后均无明显改变。结论葡萄籽提取物对人体具有抗氧化作用。
Objective To investigate the antioxidant effect of grape seed extract on human body. Methods A total of 106 healthy volunteers aged 45-65 years old were randomly divided into test group and control group according to the content of serum malondialdehyde. The test group took the test substance continuously for 180 days. Serum malondialdehyde (MDA) content and the activity and safety index of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were measured. Results The content of malondialdehyde in test group dropped significantly after the test, the rate of decrease was 5.91%, the activity of superoxide dismutase was significantly increased, which was significantly different from that of control group before and after the test (P < 0.05). The rate of increase was 17.41%. The activity of glutathione peroxidase was significantly increased with an increase rate of 7.37%. The safety indicators before and after the test had no significant change. Conclusion Grape seed extract has anti-oxidant effect on human body.