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本文设计合成了针对HBV ayw DNA前S2区第110、122和132位碱基的三靶位串联锤头状核酶基因。经序列分析证明该核酶基因的一级结构与设计序列完全相符。将核酶基因和从含有HBV ayw
In this paper, we designed and synthesized a triple-target hammerhead ribozyme gene targeting the bases 110, 122 and 132 of the pre-S2 region of HBV ayw DNA. Sequence analysis showed that the primary structure of the ribozyme gene exactly matches the designed sequence. The ribozyme gene and from containing HBV ayw