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目的探讨葡萄糖酸锌联合干扰素治疗婴幼儿轮状病毒腹泻的疗效。方法将平山县人民医院2011年2月至2012年2月收治的76例轮状病毒腹泻婴幼儿随机分为对照组和研究组,两组均给予重组人干扰素a治疗,仅研究组加用葡萄糖酸锌;分析两组的治疗效果,常见症状持续时间(发热、呕吐、腹泻和脱水),治疗时间指标(退热、止泻、总疗程和粪便轮状病毒转阴)和症状评分情况。结果研究组的治疗总有效率高于对照组(P<0.05),显效例数多于对照组(P<0.01),无效例数少于对照组(P<0.05),常见症状持续时间和治疗时间指标均短于对照组,治疗后的症状评分低于对照组(P<0.01)。结论葡萄糖酸锌联合干扰素治疗婴幼儿轮状病毒腹泻的临床效果较好,缩短常见症状的持续时间和治疗时间。
Objective To investigate the efficacy of zinc gluconate combined with interferon in the treatment of infantile rotavirus diarrhea. Methods Totally 76 infants with rotavirus diarrhea admitted from February 2011 to February 2012 in Pingshan County People’s Hospital were randomly divided into control group and study group. Both groups were treated with recombinant human interferon- Zinc gluconate was given. The treatment effect, duration of common symptoms (fever, vomiting, diarrhea and dehydration), treatment time (fever, diarrhea, total course of treatment and rotavirus droppings) and symptom score were analyzed. Results The total effective rate of the study group was higher than that of the control group (P <0.05), the number of effective cases was more than that of the control group (P <0.01), the number of invalid cases was less than that of the control group (P <0.05) The time indexes were shorter than the control group, and the symptom score after treatment was lower than that of the control group (P <0.01). Conclusion Combination of zinc gluconate and interferon is effective in treating rotavirus diarrhea in infants and young children, shortening the duration and duration of common symptoms.