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目的探讨肿瘤浸润淋巴细胞（TIL）对老年胃癌患者细胞免疫功能的作用。方法用流式细胞仪分析胃癌TIL的细胞表型及胃癌患者细胞表型的治疗变化。结果胃癌TILCD4／CD8为0．83．NK细胞为16．3％±3．6％。经IL－2激活后．CD4／CD8为1．85．NK细胞数量增至41．3％±13．7％（P＜0．01）。胃癌术后患者外周血CD4/CD8比例为1．44．NK细胞占30.67％±11．51％。接受TIL，治疗后，CD3和CD4增多，NK细胞数量增多，3年生存率明显高于单纯手术治疗组（P＜0．01）。结论TIL治疗可提高胃癌患者的细胞免疫功能．延长其生存期，可能成为胃癌术后抗肿瘤复发和转移的重要疗法。
Objective To investigate the effect of tumor infiltrating lymphocytes (TIL) on cellular immune function in elderly patients with gastric cancer. Methods Flow cytometry was used to analyze the phenotypes of gastric cancer TIL and the therapeutic phenotypes of gastric cancer patients. Results The gastric cancer TILCD4/CD8 was 0.83. NK cells were 16.3% ± 3.6%. After activation by IL-2. CD4/CD8 is 1.85. The number of NK cells increased to 41.3% ± 13.7% (P < 0.01). The ratio of CD4/CD8 in peripheral blood of patients with gastric cancer was 1.44. NK cells accounted for 30.67% ± 11.51%. After receiving TIL, after treatment, CD3 and CD4 increased, and the number of NK cells increased. The 3-year survival rate was significantly higher than that of the simple surgical treatment group (P<0.01). Conclusion TIL treatment can improve the cellular immune function of gastric cancer patients. Prolonging its survival period may be an important treatment for postoperative anti-tumor recurrence and metastasis of gastric cancer.