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目的 为了探讨牛磺酸对脑缺血再灌注损伤的作用。 方法 建立沙土鼠脑缺血再灌注模型进行实验。设立实验组G3( 注射牛磺酸组) 、实验组G2( 不用任何药物组) 及对照组G1 。处死动物后,即时分别检测各组血浆内皮素、脑组织脂质过氧化物、脑组织湿/ 干重比值、脑组织学光镜检查等。 结果 四项检测方法从不同方面证实牛磺酸对脑缺血再灌注损伤有抗自由基,稳定细胞膜,降低内皮素,保护脑组织细胞等抗脑缺血再灌注损伤的脑保护作用,与未用牛磺酸组有显著差别。 结论 为临床应用牛磺酸治疗脑缺血缺氧及缺血性脑血管病提供了实验依据
Objective To investigate the effect of taurine on cerebral ischemia-reperfusion injury. Methods The gerbil model of cerebral ischemia - reperfusion was established. The experimental group G3 (taurine injection group), the experimental group G2 (without any drug group) and the control group G1. After the animals were sacrificed, the plasma endothelin, brain tissue lipid peroxides, brain wet / dry weight ratio and brain histological light microscopy were detected immediately. Results The four test methods from different aspects confirmed that taurine on cerebral ischemia-reperfusion injury with anti-free radicals and stabilize the cell membrane, reduce endothelin, brain cells and other protective effects of cerebral ischemia-reperfusion injury, and not With taurine group there are significant differences. Conclusion The clinical application of taurine in the treatment of cerebral ischemia and hypoxia and ischemic cerebrovascular disease provides experimental evidence