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本文采用三种速率(A组10mg/kg/min×2分;B组1mg/kg/min×30分;C组0.13mg/kg/min×120分)静脉给药,观察给药速率对麻醉犬血浆药物浓度和心电图改变的影响。结果表明:以C组速率给药,可避免A组给药时血浓度急骤上升和下降的缺点,剂量虽比A组增加一半,但心电图改变稍轻;与B组相比,剂量降低一倍,心电图改变明显好转(P<0.05),而维持一定血浓度值的时间却显著延长(P<0.05),因此,临床以低速率滴注为宜。在C组给药初期,心率稍有加快,达5μg/ml浓度时,心率开始变慢并出现P-R延长和QRS综合波增宽,显示常咯啉有“奎尼丁样”作用;浓度在8μg/ml以下时,P-R和QRS阻滞未超过Ⅰ度;心电图改变与血浓度呈线性关系,其线性方程为y_1=0.00484X+0.0652(P-R间期);y_2=0.00190X+0.0456(QRS综合波),显示常咯啉对房室传导较室内传导为敏感。 本文就血浓度和心电图改变的关系,对常咯啉和奎尼丁进行了讨论。
In this study, three rates (10 mg / kg / min in group A, 1 mg / kg / min in group B and 0.13 mg / kg / min in group C) Effect of plasma drug concentration and electrocardiogram changes in dogs. The results showed that: the group C rate of administration, to avoid the blood concentration in group A administration when the sharp rise and fall of the shortcomings, although the dose than in group A increased by half, but the electrocardiogram slightly changed; compared with the group B, the dose was doubled , ECG changes significantly improved (P <0.05), while maintaining a certain blood concentration was significantly longer (P <0.05), therefore, the clinical low-rate infusion is appropriate. At the beginning of group C, the heart rate slightly increased. At the concentration of 5μg / ml, the heart rate began to slow down and the prolongation of PR and the broadening of QRS complex appeared, indicating that quinoline had a “quinidine-like” effect. At the concentration of 8μg / ml or less, PR and QRS block did not exceed Ⅰ degree; linear change of electrocardiogram and blood concentration, the linear equation was y_1 = 0.00484X + 0.0652 (PR interval); y_2 = 0.00190X + 0.0456 (QRS complex wave ), Showing that morpholine is more susceptible to atrioventricular conduction than conduction. This article discusses the relationship between blood concentrations and changes in electrocardiograms, and discusses quinoline and quinidine.