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目的对比拉莫三嗪和卡马西平治疗新就诊的部分性发作癫患者的效果。方法随机将43例新就诊的部分性发作癫患者,分别给予拉莫三嗪(A组)和卡马西平(B组)治疗,观察发作控制情况及生活质量改善情况。结果A组总有效率为90.5%(19/21),B组总有效率为90.9%(20/22),两组差异无统计学意义。A组治疗后QOLIE-31量表评分为(66±17)分,B组治疗后为(52±16)分,两组比较差异有统计学意义(P<0.05)。结论拉莫三嗪与卡马西平治疗部分性发作癫患者的效果相当,能较卡马西平更好地改善癫患者的生活质量,提示拉莫三嗪可作为治疗部分性发作癫的一线药物。
Objective To compare the efficacy of lamotrigine and carbamazepine in the treatment of newly diagnosed epileptic seizures. Methods A total of 43 newly diagnosed epilepsy patients were randomly assigned to receive lamotrigine (group A) and carbamazepine (group B). The control of seizure and quality of life were observed. Results The total effective rate was 90.5% (19/21) in group A, and 90.9% (20/22) in group B. The difference between the two groups was not statistically significant. The score of QOLIE-31 was 66 ± 17 in group A and 52 ± 16 in group B after treatment. The difference between the two groups was statistically significant (P <0.05). Conclusion Lamotrigine and carbamazepine treatment of partial seizures in patients with epilepsy is equivalent to better than carbamazepine to improve the quality of life of patients with epilepsy, suggesting that lamotrigine can be used as part of the treatment of seizures epilepsy First-line drugs.