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实验大白鼠分三组:肝损伤组给予四氧化碳(CCl_4);治疗组除给 CCl_4外,用肝炎Ⅲ号煎剂灌胃共7日;对照组皮下注射生理盐水,自来水灌胃。结果治疗组与肝损伤组相比,肝小叶损伤区域缩小,肝细胞中脂滴减少,细胞核增大,RNA 及核仁增多,糖原增加,SDH,G-6-Pase 活性增强,粗面内质网恢复平行排列,线粒体形态结构恢复,数量增加。表明肝炎Ⅲ号对肝损伤有修复作用,其机理可能是通过阻止内质网的损伤,促进蛋白质合成及解毒作用,恢复肝细胞的功能;并促进酐细胞再生。
Rats were divided into three groups: carbon tetrachloride (CCl_4) was administered to the liver injury group; in the treatment group, Hepatitis III decoction was used for intragastric administration for 7 days except for CCl_4; the control group was subcutaneously injected with normal saline and tap water was administered. Results Compared with the liver injury group, the liver lobule injury was reduced in the treatment group, the lipid droplets in the hepatocytes decreased, the nuclei increased, the RNA and nucleolus increased, the glycogen increased, and the activity of SDH and G-6-Pase increased. The restoration of the reticulum was parallel and the morphological structure of the mitochondria was restored and the number increased. It was shown that Hepatitis III can repair liver damage. The mechanism may be to prevent the damage of endoplasmic reticulum, promote protein synthesis and detoxification, restore the function of liver cells, and promote the regeneration of the anhydride cells.