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长效吡哌酸2.0g,12h口服1次,治程1d,治疗急性菌痢65例;长效吡哌酸3.0g和甲氧苄氨嘧啶0.4g并用,1次口服治疗67例。结果前组60例(92％)获愈,5例经再1短程治疗亦愈;后组1剂全部获愈。两组均未见毒副作用。治后发热者平均13.4h恢复正常,腹部症状和粪检1.5d后正常,痢疾菌2d阴转。22例出院后随访,除1例复发外,余均正常,未见带菌者。长效吡哌酸口服后,可维维较为恒定血浓度,1d治程有效血浓度可望维持48h,因而短程治疗可获佳效。
Long-acting pipemidic acid 2.0g, 12h orally 1 times, treatment 1d, the treatment of acute bacillary dysentery 65 cases; long-acting piperidinyl 3.0g and trimethoprim 0.4g and used, 1 oral treatment of 67 cases. Results In the former group, 60 cases (92%) were cured, and 5 cases were cured by another short-range treatment. The latter group was all cured. No side effects were observed in both groups. After treatment, the average fever of 13.4h returned to normal, abdominal symptoms and fecal sequestration 1.5d after normal, diarrhea 2d negative turn. 22 cases were followed up after discharge, except one case of recurrence, the remaining were normal, no carrier. Long-term piperacillin oral administration, the dimension of more constant blood concentration, effective blood concentration 1d treatment is expected to maintain 48h, which can be treated with short-term effect.