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在从人外周血单核细胞（PBMC）中诱导DC的过程中加入不同浓度的人甲胎蛋白（AFP），发现DC的数量、共刺激分子CD80的表达以及对T细胞的刺激增殖能力受到明显抑制，而AFP的这种抑制效应与其浓度有关，并能被anti—AFP单抗所拮抗。
Different concentrations of human alpha-fetoprotein (AFP) were added during the induction of DCs from human peripheral blood mononuclear cells (PBMCs). The number of DCs, the expression of co-stimulatory molecules CD80, and the stimulation of T cells were significantly increased. The inhibitory effect of AFP is related to its concentration and can be antagonized by the anti-AFP monoclonal antibody.