论文部分内容阅读
心钠素是近年来首先从大鼠和人的心房组织中分离、纯化的一类生物活性多肽。它们具有强大的利钠、利尿、扩张血管和降低血压等作用。一些研究证明,肾脏不仅是心钠素的一个主要靶器官,而且也是心钠素的一个重要代谢场所。当肾脏受到损害,心钠素的生物作用及降解就会发生障碍。本文应用特异的人心钠素抗体,通过放射免疫方法,观察了29例慢性肾脏疾病(简称慢性肾病)患者和25例健康人血浆心钠素含量,并对它在不同肾功能患者中的意义进行初步探讨。
Atrial natriuretic factor (atrial natriuretic peptide) is a class of bioactive peptides that have been isolated and purified from rat and human atrial tissues in recent years. They have a strong sodium, diuretic, dilate blood vessels and lower blood pressure and so on. Some studies have shown that the kidney is not only a major target organ of atrial natriuretic peptide, but also an important metabolic site of atrial natriuretic peptide. When the kidneys are damaged, the biological effects of atrial natriuretic peptide and degradation can occur. In this paper, we observed the plasma atrial natriuretic peptide levels in 29 patients with chronic kidney disease (CKD) and 25 healthy people by radioimmunoassay using specific human ANP antibody and evaluated its significance in patients with different renal functions Preliminary discussion.