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目的:建立毛细管气相色谱法测定消癌胶囊中麝香酮和冰片的含量方法。方法:分别采用毛细管色谱柱DB-35MS (300 m×0.25 mm,0.25μm)及DB-WAX(30 m×0.25 mm,0.25μm),采用程序升温的毛细管气相色谱法测定麝香酮和冰片的含量Fld检测器。结果:麝香酮的线性范围为4.2～168μg·ml~(1-)(r=0.9999),平均加样回收率为98.7%(n=8),RSD= 2.8%;冰片的线性范围为0.03～0.4 mg·ml~(-1)(r=0.9997),平均加样回收率为100.7%,RSD=2.5%。结论:该方法具有简便、快速、准确等特点,可有效控制本制剂的质量。
Objective: To establish a capillary gas chromatographic method for the determination of muskone and borneol in Xiaogan capsules. METHODS: Capillary gas chromatography was used to determine the content of muskone and borneol using capillary column DB-35MS (300 m×0.25 mm, 0.25 μm) and DB-WAX (30 m×0.25 mm, 0.25 μm) respectively. Fld detector. RESULTS: The linear range of muskone was 4.2-168μg·ml-(1-)(r=0.9999). The average recovery was 98.7% (n=8), RSD was 2.8%, and the linear range of borneol was 0.03～ 0.4 mg·ml -1 (r = 0.9997), the average recovery was 100.7%, RSD = 2.5%. Conclusion: This method is simple, rapid, accurate, and can effectively control the quality of the preparation.