1.背景目前胰腺癌发病率呈逐年升高的趋势,早期难以诊断,确诊时约80%以上的患者属于晚期,已无手术切除的机会,化学治疗便成为晚期胰腺癌的主要治疗手段之一[1-2]。1997年发表的一个126例III期胰腺癌患者的随机临床研究[3],首次确定吉西他滨单药化疗优于5-FU单药,从此吉西他滨30 1. Background At present, the incidence of pancreatic cancer is increasing year by year. It is difficult to diagnose in the early stage. About 80% of the patients diagnosed at the time of diagnosis are advanced and have no chance of surgical resection. Chemotherapy has become one of the main treatments for advanced pancreatic cancer [1-2]. A randomized clinical trial of 126 patients with stage III pancreatic cancer [3] published in 1997 demonstrated that gemcitabine monotherapy was the first to be superior to 5-FU monotherapy and gemcitabine 30