基因修饰将外源性基因导入目的细胞中,使得该细胞具备过表达或静默表达某种基因的能力。在干细胞治疗缺血性心脏病领域,基因修饰主要使干细胞过表达相关蛋白,有助于提高细胞移植效率、保护心脏功能和协助体内示踪等。本文就基因修饰在干细胞治疗缺血性心脏病中的运用进展进行综述。 Genetically modified foreign genes into the target cells, making the cells have the ability to overexpress or silently express a certain gene. In the field of stem cell therapy for ischemic heart disease, gene modification mainly enables stem cells to overexpress related proteins, which can help to improve the efficiency of cell transplantation, protect cardiac function and assist in vivo tracing. This article reviews the progress of gene modification in the treatment of ischemic heart disease by stem cells.