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目的:探究养血清脑颗粒对老年脑梗死后抑郁患者血清胱抑素C水平的影响及认知功能水平的影响。方法:选取2015年6月到2016年6月我院神经内科收治的老年脑梗死后抑郁患者74例,根据随机数字对照表分为对照组与试验组,各37例。对照组采用口服盐酸帕罗西汀治疗,试验组联合给予养血清脑颗粒治疗,4周为一个疗程,共治疗一个疗程。比较两组患者临床疗效、血清胱抑素C水平及认知功能水平。结果:治疗结束后,与对照组相比,试验组临床总有效率较高(P<0.05),治疗后两组血清胱抑素C水平较治疗前降低(P<0.05),MMSE评分较治疗前升高(P<0.05);与对照组相比,血清胱抑素C水平较低(P<0.05),MMSE评分较高(P<0.05)。结论:养血清脑颗粒治疗老年脑梗死后抑郁患者临床疗效显著,认知功能明显改善,推测其与血清胱抑素C水平降低有关。
Objective: To investigate the effect of Yangxue Qingnao granule on the level of serum cystatin C in elderly patients with post-stroke depression and the effect of cognitive function. Methods: Seventy-four elderly patients with depression after cerebral infarction admitted to our department of neurology from June 2015 to June 2016 were divided into control group and experimental group according to random number table, 37 cases in each group. The control group was treated with oral paroxetine hydrochloride. The experimental group was treated with Yangxue Qingnao Granule. Four weeks was a course of treatment, and a total of one course of treatment was treated. The clinical efficacy, serum cystatin C level and cognitive function were compared between the two groups. Results: Compared with the control group, the total clinical effective rate was significantly higher in the experimental group (P <0.05) after treatment, and the level of serum cystatin C in the two groups decreased after treatment (P <0.05) (P <0.05). Compared with the control group, serum cystatin C level was lower (P <0.05) and MMSE score was higher (P <0.05). CONCLUSION: Yangxue Qingnao Granules has significant clinical effect and cognitive function in elderly patients with depression after cerebral infarction. It is presumed that it has something to do with the decrease of serum cystatin C level.