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阿片滥用能引起依赖和成瘾,并伴有神经损伤。阿片的神经毒性与阿片致脑内神经元氧化应激反应、细胞凋亡以及抑制神经元发生有关。了解阿片神经毒性机制有助于改善阿片成瘾的治疗。
Opioid abuse can cause dependence and addiction, and accompanied by nerve damage. Opioid neurotoxicity and opioid brain neurons oxidative stress response, apoptosis and inhibition of neuronal occurrence. Understanding the neurotoxic mechanism of opioids helps to improve opiate addiction treatment.