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卡托普利(巯甲丙脯酸)为一新型的血管紧张素转化酶抑制剂,临床用于治疗高血压和充血性心力衰竭,但半衰期短。为延长药物作用时间和提高药效,本文合成了它的酯类衍生物。初步药理试验结果表明,某些酯类化合物呈现明显降压恬性和延长作用时间。
Captopril (captopril) is a novel angiotensin-converting enzyme inhibitor, clinically used for the treatment of hypertension and congestive heart failure, but the short half-life. In order to prolong the drug action time and improve the efficacy, this paper synthesized its ester derivatives. Preliminary pharmacological test results show that some ester compounds showed significant depression and prolonged action time.