论文部分内容阅读
内质网甘露糖苷酶-Ⅰ样蛋白(EDEM)是受内质网应激诱导之后,启动内质网相关糖蛋白降解(GERAD)途径发生的一种有酶结构域但无酶活性的蛋白。现就EDEM编码基因及其蛋白质的结构与功能解析、EDEM参与的GERAD途径,特别是EDEM的作用机制及诱导调控等诸方面予以综述。
Endoplasmic reticulum The mannosidase-I-like protein (EDEM) is an enzymatically active but enzymatically inactive protein that initiates the endoplasmic reticulum-associated glycoprotein degradation (GERAD) pathway after being induced by endoplasmic reticulum stress. The structure and function of EDEM coding genes and their proteins, the GERAD pathway involved in EDEM, especially the mechanism of action and induction regulation of EDEM are summarized.