报道了二价钯催化的高选择性芳基C—H键的三氟甲硫基化反应,其中稳定的三氟甲硫基苯胺2a作为三氟甲硫基试剂,醋酸钯作为催化剂,苯甲酰氯和醋酸银作为添加剂,反应在DMF中120℃条件下实现的.各种取代的吡啶都可以作为该反应的导向基团.反应中苯甲酰氯的添加对活化三氟甲硫基苯胺2a起着关键作用.该反应为合成邻位三氟甲硫基取代苯类衍生物提供了高效方便的方法. Reported the bivalent palladium-catalyzed trifluoromethylsulfenation of highly selective aryl C-H bonds, wherein the stable trifluoromethylthioaniline 2a as the trifluoromethylthio reagent and the palladium acetate as the catalyst, the benzyl Acyl chloride and silver acetate as additives, the reaction was carried out in DMF at 120 ° C. A variety of substituted pyridine can be used as a guide to the reaction. The reaction of benzoyl chloride added to the activated trifluoromethylthioaniline 2a Plays a key role.The reaction provides an efficient and convenient method for the synthesis of ortho-trifluoromethylthio-substituted benzene derivatives.