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目的探讨脑钠肽联合同型半胱氨酸对老年脑梗死的诊断价值。方法回顾性分析该院收治的83例老年脑梗死患者,根据患者病程分为急性期33例和非急性期50例;根据颈动脉彩色多普勒超声分为MS组40例和SS组43例;并以同期入院体检的44例健康志愿者为对照组,分别比较各组患者脑钠肽及同型半胱氨酸水平。结果以病程分组:患者急性期BNP与Hcy水平均显著高于亚急性(P<0.05),亚急性期患者BNP与Hcy水平显著高于空白组(P<0.05)。以颈动脉狭窄程度分组:对照组、MS组、及SS组的BNP与Hcy水平均依次显著升高,且组与组之间差异有统计学意义(P<0.05)。结论发病时期和颈动脉梗死程度对BNP与Hcy的含量均有显著影响,BNP与Hcy联合检测对于老年脑梗死的发病和进程均有一定的预测价值。
Objective To investigate the diagnostic value of brain natriuretic peptide and homocysteine in senile cerebral infarction. Methods A retrospective analysis of 83 elderly patients with cerebral infarction admitted to the hospital, according to the duration of the disease were divided into acute and non-acute cases in 50 cases; according to carotid artery color Doppler ultrasound was divided into MS group 40 cases and SS group 43 cases ; 44 healthy volunteers who were admitted to the hospital during the same period were taken as the control group to compare the levels of brain natriuretic peptide and homocysteine in each group. The results were grouped according to the course of disease: The levels of BNP and Hcy in patients were significantly higher than those in patients with acute subacute (P <0.05). The levels of BNP and Hcy in subacute patients were significantly higher than those in blank group (P <0.05). Grouping with the degree of carotid stenosis: The levels of BNP and Hcy in control group, MS group and SS group were significantly increased in turn, and the difference between the two groups was statistically significant (P <0.05). Conclusions The onset of disease and the degree of carotid artery infarction have a significant effect on the content of BNP and Hcy. Combined detection of BNP and Hcy has certain predictive value in the pathogenesis and progression of senile cerebral infarction.