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研制一种特异性亲炎症或感染部位的示踪定位显像剂９９ｍＴｃ标记的人多克隆免疫球蛋白Ｇ（ＨＩＧ）．方法：用２-亚氨基硫烷修饰ＨＩＧ，制备冷冻干燥９９ｍＴｃ标记一步法药盒，测定该药盒及其标记产物９９ｍＴｃ-ＨＩＧ的理化性质、生物性能，初步试用于临床．结果：室温下该药盒经与９９ｍＴｃＯ混合后，立即得到标记年大于９９％的９９ｍＴｃ-ＨＩＧ，标记方法简单便利；标记后室温保存２４小时，放化纯度仍大于９０％，产物稳定性好；在炎症／感染动物模型上，示踪剂定位明确．Ｔ／Ｂ值高；药盒的各项技术指标符合药典体内诊断试剂的规定．结论：经初步临床试用，诊断价值肯定，特别适合于我国国情．
Development of a 99mTc-labeled human polyclonal immunoglobulin G (HIG) with a specific affinity for inflammation or site of infection. Methods: HIG was modified with 2-iminothiolane to prepare lyophilized 99mTc labeled one-step kit. The physicochemical properties and biological properties of 99mTc-HIG were assayed. The kit was initially tested in clinic. Results: After the kit was mixed with 99mTcO at room temperature, the 99mTc-HIG with the labeling of more than 99% was obtained immediately. The labeling method was simple and convenient. After the labeling was stored at room temperature for 24 hours, the radiochemical purity was still above 90% Tracer localization is well established in an inflammatory / infectious animal model. T / B value is high; the technical indicators of the kit are in accordance with the provisions of the Pharmacopoeia diagnostic reagent in vivo. Conclusion: After preliminary clinical trial, the diagnostic value is affirmative, especially suitable for our national conditions.