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目的评价胃镜下光动力疗法治疗上消化道恶性肿瘤的适应证、疗效和安全性。方法上消化道肿瘤患者14例。其中胃癌7例,食管癌7例。静脉注射光敏剂photosan(2mg/kg)48小时后、血啉甲醚(5mg/kg)24小时后应用氦氖激光经胃镜对病灶部位进行照射,治疗1月后复查胃镜观察病灶变化。结果 14例患者的显效率为78.6%,总有效率为92.9%,食管癌患者显效率为85.7%,胃癌患者显效率为71.4%。两种疾病之间的总有效率无显著性差异(P>0.05)。治疗的主要不良反应有反酸、恶心以及照射部位疼痛。结论光动力治疗上消化道肿瘤适用于不宜手术切除的晚期或高龄食管癌和胃癌患者,近期的局部疗效显著,是一种安全的肿瘤治疗方法。
Objective To evaluate the indications, efficacy and safety of endoscopic photodynamic therapy for upper gastrointestinal malignancies. Methods 14 cases of upper gastrointestinal cancer patients. Including 7 cases of gastric cancer, esophageal cancer in 7 cases. 48 hours after the intravenous photosensitizer photosan (2mg / kg), hematoporphyrin (5mg / kg) 24 hours after the application of He-Ne laser by gastroscopy on the lesion site irradiation, after 1-month review of endoscopic observation of lesions. Results The effective rate was 78.6% in 14 patients, the total effective rate was 92.9%, the effective rate was 85.7% in esophageal cancer patients and 71.4% in gastric cancer patients. There was no significant difference between the two diseases (P> 0.05). The main side effects of treatment are acid reflux, nausea and irradiation site pain. Conclusion Photodynamic therapy for upper gastrointestinal cancer is not suitable for surgical resection of advanced or advanced esophageal and gastric cancer patients, the recent local curative effect is significant, is a safe method of cancer treatment.