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目的 探讨移植肾IgA肾病的病理特征、临床表现及预后。方法 回顾分析移植肾穿刺活检病理及临床资料。结果 3例IgA肾病 ,1例为复发性膜增殖型 ,2例为复发 /新发性系膜增殖型 ,临床表现主要是镜下血尿、轻度蛋白尿、或 /和高血压、高脂血症 ;病理改变与普通人群的IgA肾病相同 ,此外存在多灶性肾小管萎缩及间质纤维化 ;其对治疗的反应与病理改变密切相关 ,以双嘧达莫、小剂量华法林及雷公藤多甙治疗 2年 ,2例系膜增殖型者肾功能稳定 ,膜增殖型的 1例治疗 2年半后血肌酐上升。结论 移植肾IgA肾病复发迅速 ,其进展速度及治疗效果与病理分型和病变程度密切相关 ,无特效治疗方法
Objective To investigate the pathological features, clinical features and prognosis of renal transplant recipients with IgA nephropathy. Methods Retrospective analysis of renal biopsy pathology and clinical data. Results IgA nephropathy in 3 cases, 1 case of recurrent membrane proliferative, 2 cases of recurrent / new mesangial proliferative, clinical manifestations are mainly microscopic hematuria, mild proteinuria, and / or hypertension, hyperlipidemia Symptoms; pathological changes and the general population of IgA nephropathy the same, in addition to the existence of multifocal tubular atrophy and interstitial fibrosis; its response to treatment and pathological changes are closely related to dipyridamole, low-dose warfarin and Ray Gong Two years of treatment with tylosin, 2 cases of mesangial proliferative kidney function was stable, one case of membrane proliferation of serum creatinine increased after 2 and a half years of treatment. Conclusion IgA nephropathy relapse rapidly, its progress rate and treatment effect is closely related to the pathological type and degree of disease, no specific treatment