以中链甘油三酯为油相,蛋黄卵磷脂和泊洛沙姆188为乳化剂,采用高压乳匀法制备普罗布考亚微乳剂。以平均粒径、多分散系数(PDI)、电位和稳定性等评价指标优化了处方。按优化条件制得的普罗布考亚微乳稳定性良好,平均粒径(168.8±1.5)nm,电位(-50.1±1.7)mV,载药量为(4.2±1.6)mg/ml。 Using medium-chain triglyceride as oil phase, egg yolk lecithin and poloxamer 188 as emulsifier, probucol microemulsion was prepared by high pressure homogenization. The prescriptions were optimized with evaluation indexes such as average particle size, polydispersity (PDI), potential and stability. Probucol microemulsion prepared under optimized conditions had good stability with an average particle size of (168.8 ± 1.5) nm and a potential of (-50.1 ± 1.7) mV with a drug loading of (4.2 ± 1.6) mg / ml.