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目的:探讨CEA、CA19-9、CA125和CA72-4不同组合在结直肠癌诊断中的临床意义。方法:回顾性分析分析我院2010年1月-2011年12月确诊的结直肠癌患者373例的临床资料。结果:373例结直肠癌患者中,单一检测CEA、CA19-9、CA125和CA72-4阳性率为24.4%-48.3%,其中CEA阳性率为48.3%,阳性率最高;同时检测两个指标,任一个指标大于正常值的阳性率为38%-55.3%,其中CEA+CA19-9阳性率为55.3%,阳性率最高,与CEA+CA125(阳性率为55%)比较,无统计学意义(P>0.05),与其他组合及单一检测CEA比较有统计学意义;检测三个指标,任一个指标大于正常值的阳性率为46.3%-60.6%,其中CEA+CA19-9+CA125阳性率为60.6%,阳性率最高,与CEA+CA19-9两个指标比较,有统计学意义;同时检测四个指标,任一个指标大于正常值的阳性率为61.2%,虽然比CEA+CA19-9+CA125阳性率高,但无统计学意义。结论:联合检测CEA、CA19-9、CA125和CA72-4可以提高结直肠癌诊断的阳性率,其中联合检测CEA+CA19-9+CA125三个指标是最优组合。
Objective: To investigate the clinical significance of different combinations of CEA, CA19-9, CA125 and CA72-4 in the diagnosis of colorectal cancer. Methods: The clinical data of 373 colorectal cancer patients diagnosed in our hospital from January 2010 to December 2011 were analyzed retrospectively. Results: The positive rate of CEA, CA19-9, CA125 and CA72-4 was 24.4% -48.3% in 373 cases of colorectal cancer. The positive rate of CEA was 48.3% and the positive rate was the highest. The positive rate of any one index was higher than normal ranged from 38% to 55.3%, of which the positive rate of CEA + CA19-9 was 55.3%, the highest positive rate was not statistically significant compared with CEA + CA125 (positive rate was 55%) P> 0.05), with other combinations and single detection of CEA was statistically significant; detection of three indicators, any one index greater than the normal positive rate was 46.3% -60.6%, of which CEA + CA19-9 + CA125 positive rate was 60.6%, the highest positive rate, with CEA + CA19-9 two indicators, statistically significant; Simultaneous detection of four indicators, any one index greater than the normal positive rate was 61.2%, although higher than the CEA + CA19-9 + The positive rate of CA125 was high, but not statistically significant. Conclusion: The combined detection of CEA, CA19-9, CA125 and CA72-4 can improve the positive rate of colorectal cancer diagnosis, and the combination of CEA + CA19-9 + CA125 three indicators is the optimal combination.