近来CD4+CD25+调节性T细胞对肿瘤免疫调节的抑制作用正受到越来越多的重视,许多恶性肿瘤患者外周血都存在CD4+CD25+调节性T细胞比例上调,机体抗肿瘤免疫力下降。大肠癌的发病率正逐年上升,其发病分子机制已为熟知,免疫机制研究不多,国内尚未见大肠癌与该类细胞关系的报道,现对CD4+CD25+调节性T细胞在大肠癌的发生、发展、治疗中的研究综述如下。 Recently, the inhibitory effect of CD4 + CD25 + regulatory T cells on tumor immunoregulation is receiving more and more attention. In many peripheral blood of patients with malignant tumors, the proportion of CD4 + CD25 + regulatory T cells is up-regulated and the anti-tumor immunity of the body is decreased. The incidence of colorectal cancer is increasing year by year, the molecular mechanism of its pathogenesis is well known, few studies on the immune mechanism, no reports of the relationship between colorectal cancer and such cells have been reported in China, and the occurrence of CD4 + CD25 + regulatory T cells in colorectal cancer The development and treatment of research summarized below.