目的:探讨兰索拉唑致过敏性休克的临床特征、发病机制及后续治疗方案.方法:对1例兰索拉唑致过敏性休克的病例进行分析,并在全球范围内对类似文献报道进行复习.结果:本例患者为61岁男性,过敏症状出现在静脉输注30 mg兰索拉唑约5 min后,经及时抢救,约1 h后患者好转.文献复习查阅到的其他5例兰索拉唑致过敏性休克的报道,患者年龄在43 ~ 74岁,用药后20 min内出现潮红、血压下降等表现,4例在2 h内好转,1例死亡.结论:兰索拉唑用药1 h内,应严密观察患者,一旦出现过敏表现,及时停药并立即抢救.“,”Objective: This study is designed to investigate clinical features, pathogenesis, and follow-up treatment regimen of anaphylactic shock induced by lansoprazole. Methods: Analysis was conducted on one case of anaphylactic shock developed after administration of lansoprazole, and similar literatures were reviewed via searching Pubmed and Embase. Results: Clinical symptoms of the patient in our hospital appeared at 5 minutes after intravenous administration of 30mg lansoprazole, and relieved approximately 1 hour later after giving active and prompt rescue. In the other 5 cases aged between 43 and 74 years old, clinical symptoms appeared after 20 minutes, such as generalized flushing and drop in blood pressure. With active and prompt rescue, 4 cases recovered within 2 hours while 1 case died. Conclusion: Close monitoring must be given during the first hour after lansoprazole administration. Emergency rescue measures should be taken immediately once allergy occurs.