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目的:探讨卵巢上皮性癌脑转移的发生率、诊断、治疗和预后。方法:回顾性分析1993年—2002年收治的卵巢上皮性癌387例,12例发生脑转移的临床资料。结果:卵巢上皮性癌脑转移的发生率为3.2 %。12例患者的中位生存期为6个月,其中4例未完成治疗者生存期为1.5个月,8例完成治疗者为7个月,3例手术切除者为13个月,3例全脑放疗者为6个月,2例行颅脑放射治疗和立体定向放疗者为8个月;6例单灶转移者为10个月,6例多灶转移者为5个月;3例无其他远处转移者为9个月,9例有其他远处转移者为3.8个月。结论:转移灶的数目和有无其他远处转移是影响预后的重要因素;联合应用手术、颅脑放疗、立体定向放疗和化疗可明显缓解病情,改善症状和生存期。
Objective: To investigate the incidence of brain metastases, diagnosis, treatment and prognosis of epithelial ovarian cancer. Methods: The clinical data of 387 cases of ovarian epithelial carcinoma and 12 cases of brain metastases from 1993 to 2002 were retrospectively analyzed. Results: The incidence of brain metastases in ovarian epithelial cancer was 3.2%. The median survival of 12 patients was 6 months, of which 4 patients did not complete the survival of 1.5 months, 8 patients completed the treatment for 7 months, 3 cases of surgical resection for 13 months, 3 cases of all Brain radiation was 6 months, 2 were treated with cranial radiation therapy and stereotactic radiotherapy for 8 months; 6 cases of single-site metastasis for 10 months, 6 cases of multi-focal metastasis for 5 months; 3 cases without Other distant metastases were 9 months and 9 other distant metastases were 3.8 months. Conclusion: The number of metastases and the presence of other distant metastases are important prognostic factors. The combined application of surgery, cranial radiation therapy, stereotactic radiotherapy and chemotherapy can significantly relieve the symptoms and improve the symptoms and survival.