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目的 :研究淫羊藿黄酮及其磷脂复合物 (EFL)中淫羊藿苷在SD大鼠体内药动学。方法 :以HPLC测定法测定大鼠血中淫羊藿苷的含量 ,以同组大鼠 (8只 ,♂♀各半 )交叉灌服淫羊藿黄酮及其磷脂复合物 ,药 时曲线数据经 3P87药动学计算程序处理。结果 :分别以淫羊藿黄酮及其磷脂复合物给SD大鼠灌胃 (剂量为淫羊藿苷 10 0mg·kg-l) ,淫羊藿苷的药 时过程符合一级动力学模型 ,淫羊藿黄酮中淫羊藿苷的AUC、Cmax、Tmax分别为 (6 2 .5± 4.7)mg·h·L-1,(5 .3± 1.6 )mg·L-1,(2 .9±0 .9)h ,而EFL中的为 (15 6 .1± 2 7.2 )mg·h·L-1,(17.5± 3.5 )mg·L-1,(2 .1± 0 .6 )h ,统计结果表明AUC、Cmax之间差异有显著性。结论 :磷脂可提高淫羊藿黄酮中淫羊藿苷在大鼠体内的吸收
Objective: To study the pharmacokinetics of icariin in Epimedium flavonoids and its phospholipid complex (EFL) in SD rats. METHODS: The content of Icariin in rat blood was determined by HPLC. The rats of the same group (8 rats, half females and half females) were used to cross-dosage Epimedium flavonoids and their phospholipid complexes. 3P87 pharmacokinetic calculation program processing. RESULTS: Epimedium flavone and its phospholipid complex were intragastrically administered to SD rats (the dose was icariin 100 mg·kg-l). The drug-time course of icariin met the first-order kinetic model. The AUC, Cmax, and Tmax of icariin in sheep flavonoids were (6 2 .5± 4.7) mg·h·L-1, (5.3 ± 1.6) mg·L-1, (2.9 ± 0 .9)h, while in the EFL it is (15 6 .1± 2 7.2) mg·h·L-1, (17.5± 3.5) mg·L-1, (2.1±0.6)h, The statistical results show that the differences between AUC and Cmax are significant. Conclusion : Phospholipid can increase the absorption of icariin in epimedium flavonoids in rats