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目的 :对慢性浅表性胃炎 (CGS)患者行幽门螺杆菌 (HP)及空腹血清胃泌素 (SG)检测 ,对HP( +)组和HP( -)组SG作对比 ,抗HP治疗前后SG、病理组织学作比较 ,探讨两者与CSG的关系。方法 :患者先行空腹作SG测定 ,再作胃镜检查 ,取胃窦粘膜 3块 ,分别作快速尿素酶试验、Giemsa染色及病理组织学检查。HP( +)组抗HP治疗 ,1月后重复上述检查。结果 :HP( +)组SG明显高于HP( -)组 (P <0 .0 5 ) ,治疗后HP转阴组较非转阴组SG明显下降 (P <0 .0 5 ) ,胃粘膜中性粒细胞浸润明显减轻。结论 :HP是CSG的主要病因 ,其刺激胃泌素释放增多是导致胃粘膜炎症的重要机制。
OBJECTIVE: To detect Helicobacter pylori (HP) and fasting serum gastrin (SG) in patients with chronic superficial gastritis (CGS), compare HP with HP (-) group and SG group before and after HP treatment SG, histopathological comparison to explore the relationship between the two and CSG. Methods: The patients were subjected to fasting for SG, then gastroscopy. Three gastric mucosa were taken for rapid urease test, Giemsa staining and histopathological examination. HP (+) group anti-HP treatment, after 1 month repeat the above test. Results: The SG of HP (+) group was significantly higher than that of HP (-) group (P <0.05). After treatment, SG in HP negative group was significantly lower than that in non-negative SG (P <0.05) Neutrophil infiltration significantly reduced. Conclusion: HP is the main cause of CSG. It stimulates the increase of gastrin release and is an important mechanism of gastric mucosal inflammation.