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给以大剂量肾上腺糖皮质激素可造成动物胸腺发生急性萎缩和肾上腺切除导致胸腺肥大的现象已有不少实验材料证实。因此,有的学者认为病毒感染所引起的胸腺急性萎缩可能是肾上腺糖皮质激素的作用。据报导,急性细菌或病毒感染时,如丹毒、麻疹、水痘、细菌性肺炎及各型急性脑膜炎等患者肾上腺皮质醇的生成量高于正常1.5—6.0倍。新近,Smith和孙志坚等分别测定新城鸡瘟病毒感染小鼠和流行性出血热患者血浆糖皮质激素含量,结果均显著高于正常。
Given large doses of glucocorticoids can cause acute thymic gland contraction and adrenalectomy led to thymus hypertrophy phenomenon has been confirmed by many experimental materials. Therefore, some scholars believe that acute infection caused by thymus may be the role of the adrenal glucocorticoid. It has been reported that the production of adrenal cortisol in patients with acute bacterial or viral infections such as erysipelas, measles, chickenpox, bacterial pneumonia and various types of acute meningitis is 1.5-6.0 times higher than normal. Recently, Smith and Sun Zhijian were determined in Newcastle disease virus-infected mice and patients with epidemic hemorrhagic fever plasma glucocorticoid levels, the results were significantly higher than normal.