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P-选择素是反映血小板活化程度的特异性标志,其介导白细胞与血小板和内皮细胞的黏附,促使细胞内一些活性物质的释放,造成血小板活化、血管内皮受损并能激活凝血系统导致血栓性疾病的发生。P-选择素是启动和维持炎症的重要因子,大量炎性因子导致心肌间质纤维化和动脉粥样硬化形成,炎性反应以及缺血缺氧导致心肌细胞结构和功能的紊乱参与了糖尿病心脏病的发生和发展。对P-选择素与糖尿病心脏病的关系进行深入的研究,将为糖尿病心脏病早期防治提供新的思路和方法。
P-selectin is a specific marker reflecting the degree of platelet activation, which mediates the adhesion of leukocytes to platelets and endothelial cells, releases some of the active substances in the cells, activates platelets, damages endothelial cells and activates the coagulation system to cause thrombus The occurrence of sexually transmitted diseases. P-selectin is an important factor in the initiation and maintenance of inflammation. A large number of inflammatory factors lead to the formation of myocardial interstitial fibrosis and atherosclerosis. The inflammatory reaction and the disturbance of structure and function of myocardial cells due to ischemia and hypoxia are involved in the heart of diabetic Occurrence and development of the disease. In-depth study of the relationship between P-selectin and diabetic heart disease will provide new ideas and methods for the early prevention and treatment of diabetic heart disease.