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目的探讨硫氧还蛋白(Srx)和β-联蛋白(β-catenin)在宫颈鳞状细胞癌(CSCC)组织中的表达及临床意义。方法免疫组织化学法检测正常宫颈上皮、宫颈上皮内瘤变(CIN)以及CSCC组织中Srx与β-catenin的表达,分析与CSCC临床病理指标的关系,探讨Srx与β-catenin表达的相关性。结果 Srx与β-catenin的表达在CIN组织、宫颈癌中均显著高于正常宫颈组织,并且Srx与β-catenin表达呈正相关。Srx的表达与淋巴结转移、脉管浸润、浸润深度有关;β-catenin的表达与肿瘤转移、组织分级、FIGO分期密切相关。结论 Srx和β-catenin在CSCC中高表达且与恶性程度相关。
Objective To investigate the expression and clinical significance of thioredoxin (Srx) and β-catenin in cervical squamous cell carcinoma (CSCC). Methods Immunohistochemistry was used to detect the expression of Srx and β-catenin in normal cervical epithelium, cervical intraepithelial neoplasia (CIN) and CSCC tissues. The relationship between the expression of Srx and β-catenin in CSCC tissues and the clinicopathological parameters was analyzed. Results The expressions of Srx and β-catenin in cervical intraepithelial neoplasia were significantly higher than those in normal cervical tissues, and the expressions of Srx and β-catenin were positively correlated. The expression of Srx was related to lymph node metastasis, vascular invasion and depth of invasion. The expression of β-catenin was closely related to tumor metastasis, histological grade and FIGO stage. Conclusion Srx and β-catenin are highly expressed in CSCC and correlated with the degree of malignancy.