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目的:评价中医药序贯模式对Ⅲ/Ⅳ期胃癌患者的临床疗效。方法:选取2015年2月—2016年3月间收治的Ⅲ/Ⅳ期胃癌患者76例,将其随机分为观察组和对照组,每组38例;观察组患者均给予中医药序贯疗法治疗,对照组患者均给予中医药巩固治疗,比较两组患者治疗后的总有效率、不良反应的发生率与生存率。结果:观察组患者治疗后的总有效率为86.84%明显高于对照组为60.53%(P<0.05);不良反应的发生率为15.79%明显低于对照组为39.47%(P<0.05);1年生存率、2年生存率和3年的生存率分别为84.21%,65.79%和47.37%,明显高于对照组分别为63.16%,39.47%和23.68%(P<0.05)。结论:采用中医药序贯疗法治疗Ⅲ/Ⅳ期胃癌患者的总有效率高于中医药巩固治疗,降低了不良反应的发生率,提高了患者的生存率。
Objective: To evaluate the clinical efficacy of TCM sequential therapy in patients with stage Ⅲ / Ⅳ gastric cancer. Methods: A total of 76 patients with stage Ⅲ / Ⅳ gastric cancer who were admitted between February 2015 and March 2016 were randomly divided into observation group and control group, with 38 cases in each group. Patients in observation group were given sequential therapy of traditional Chinese medicine The patients in the control group were treated with TCM consolidation therapy. The total effective rate, the incidence of adverse reactions and the survival rate were compared between the two groups. Results: The total effective rate of the observation group was 86.84%, which was significantly higher than that of the control group (60.53%, P <0.05). The incidence of adverse reactions was 15.79%, which was significantly lower than that of the control group (39.47%, P <0.05). The 1-year survival rate, 2-year survival rate and 3-year survival rate were 84.21%, 65.79% and 47.37%, respectively, which were significantly higher than those in the control group (63.16%, 39.47% and 23.68%, P <0.05). Conclusion: The total effective rate of patients with stage Ⅲ / Ⅳ gastric cancer treated by sequential therapy of traditional Chinese medicine is higher than that of traditional Chinese medicine consolidation therapy, reducing the incidence of adverse reactions and increasing the survival rate of patients.