论文部分内容阅读
目的研究不同剂量丁苯酞治疗脑梗塞的近期疗效及作用机制。方法选取郑州市第十五人民医院2014年3月—2015年3月期间收治的脑梗塞患者66例,以随机数表法分为A、B两组,每组33例,两组入院后均在接受常规治疗基础上给予静脉滴注不同剂量丁苯酞氯化钠注射液,A组为常规剂量,B组为大剂量。比较两组临床治疗疗效,检测超敏C-反应蛋白(CRP)、白细胞介素-6(IL-6),采用美国国立卫生研究院卒中量表(NIHSS)评分评估两组脑梗塞及神经受损严重程度,并观察两组不良反应发生情况。结果 B组总有效率为90.91%显著高于A组69.70%(P<0.05);两组治疗前血清CRP、IL-6水平比较无明显差异(P>0.05),治疗后两组血清CRP、IL-6水平为均明显降低(P<0.05),且B组较A组血清CRP、IL-6水平(7.11±2.14)mg/L、(17.42±3.46)ng/L降低更显著(P<0.05);治疗前两组NIHSS评分比较无明显差异(P>0.05),治疗后两组NIHSS评分均明显降低(P<0.05),且B组较A组NIHSS评分(7.11±1.02)降低更显著(P<0.05);两组不良反应发生情况比较无统计学意义(P>0.05)。结论与常规剂量相比,大剂量丁苯酞治疗脑梗塞的近期临床疗效更显著,对降低CRP、IL-6水平及NIHSS评分有更积极的影响,且不会增加不良发应率,安全性高,可适当推荐使用。
Objective To study the short-term curative effect and mechanism of different doses of butylphthalide on cerebral infarction. Methods Sixty-six patients with cerebral infarction who were admitted to the 15th People’s Hospital of Zhengzhou City from March 2014 to March 2015 were divided into A and B groups by random number table, with 33 cases in each group. After admission, On the basis of routine treatment, different doses of butylphthalide and sodium chloride injection were given intravenously. Group A was a conventional dose and group B was a high dose. The curative effect of the two groups was compared. The levels of high sensitive C-reactive protein (CRP) and interleukin-6 (IL-6) were detected. The cerebral infarction and nerve involvement were evaluated by the National Institutes of Health Stroke Scale (NIHSS) The severity of the damage, and observe the two groups of adverse reactions occurred. Results The total effective rate in group B was 90.91%, which was significantly higher than that in group A (69.70%, P <0.05). There was no significant difference in serum CRP and IL-6 before treatment between two groups (P> 0.05) (P <0.05). The serum levels of CRP and IL-6 in group B were significantly lower than those in group A (7.11 ± 2.14) mg / L and (17.42 ± 3.46) ng / L, 0.05). There was no significant difference in the NIHSS scores between the two groups before treatment (P> 0.05). NIHSS scores of both groups were significantly decreased (P <0.05), and the NIHSS score of group B was significantly lower than that of NIHSS score of group A (7.11 ± 1.02) (P <0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion Compared with the conventional dose, high-dose butylphthalide treatment of cerebral infarction in the short term clinical efficacy is more significant, to reduce CRP, IL-6 levels and NIHSS score have a more positive impact, and will not increase the rate of bad hair, safety High, may be appropriate to recommend use.