实现蛋白质和多肽类药物的口服给药是药物递送长期追求的目标 ,具有很好的发展前景 ,同时也存在许多问题。渗透性、稳定性及在胃肠内的转运时间等是影响该类药物口服吸收的因素 ,但分子大小一般认为是最主要的障碍。本文主要介绍处方组成、包囊技术、大分子复合物和化学修饰四 Oral administration of protein and peptide drugs is the long-sought goal of drug delivery, has good prospects for development, but also has many problems. Permeability, stability and transit time in the stomach and intestine are factors that influence the oral absorption of these drugs, but molecular size is generally considered to be the most important hurdle. This article describes the prescription composition, cysts, macromolecular complexes and chemical modification four