目的:对排斥反应的分类,诊断标准及免疫抑制剂FK506的临床应用和肝肾毒性加以综述。方法:查阅近年来国内外相关文献,对其进行分析比较。结果:在器官移植领域,免疫抑制剂FK506具有高效,不良反应少等优点,但仍不可忽略其肝肾毒性。结论:FK506是一种很有前途的免疫抑制剂,以其众多优点和广泛作用逐渐成为器官移植和自身免疫性疾病的首选药物。 OBJECTIVE: To review the classification of rejection, diagnostic criteria and clinical application of immunosuppressant FK506 and hepatorenal toxicity. Methods: Access to relevant literature at home and abroad in recent years, its analysis and comparison. Results: In the field of organ transplantation, the immunosuppressive agent FK506 has the advantages of high efficiency and less adverse reactions, but its liver and kidney toxicity can not be neglected. Conclusion: FK506 is a promising immunosuppressive agent, which has become the drug of choice for organ transplantation and autoimmune diseases with its many advantages and extensive functions.