原发性巨球蛋白血症（Waldenstrom＇sMacroglobulinemia，以下简称WM）是B淋巴细胞的恶性增殖性疾病。1944年由Waldenstrom首先描述。国内少见报道，为提高对本病认识，本文总结1970年以来收治WM7例，所有患者符合国内WM诊断标准[1]，结合文献分析讨论如下。1临床资料1．1临床 Walglass’s disease macroglobulinemia (hereinafter referred to as WM) is a malignant proliferative disease of B lymphocytes. Described first by Waldenstrom in 1944. The rare domestic reports, in order to improve understanding of the disease, this article summarizes WM7 since 1970, all patients with the domestic WM diagnostic criteria [1], combined with the literature analysis discussed below. 1 clinical data 1.1 clinical