论文部分内容阅读
地高辛径由肝脏和肾脏消除,其中肾脏消除方式有肾小球过滤和肾小管分泌二种。安体舒通是醛固酮的拮抗剂,可抑制地高辛的肾小管分泌和肾清除率,本文阐明两药相互作用的临床意义。受试者8人(健康者4人,患有血管硬化的心脏病4人),比较单用地高辛(0.75 mg)及并用安体舒通(100 mg,一天二次)时对地高辛在体内消除的影响。在静脉注射地高辛后不同时间内取血、尿样本,用放射免疫法测定地高辛血浆中浓度及尿中排泄量,计算出血浆清除率、分布容积及肾和肾外清除率。结果并
Digoxin diameter by the liver and kidneys to eliminate, including kidney elimination of glomerular filtration and tubular secretion of two kinds. Spironolactone is an aldosterone antagonist that inhibits digoxin in tubular secretion and renal clearance. This article illustrates the clinical significance of the interaction between the two drugs. Eight subjects (four healthy, four with a hardening heart disease) compared digoxin (0.75 mg) and spironolactone (100 mg once a day) against digoxin The effect of elimination in the body. Plasma and urine samples were taken at different times after intravenous injection of digoxin, plasma concentrations of digoxin in plasma and urinary excretion were determined by radioimmunoassay, and the plasma clearance, volume of distribution, and renal and extrarenal clearance were calculated. Results and